Did tobacco become popular because it kills parasites?

While reading about the conditions in a Burmese prison around the turn of the previous century (The History and Romance of Crime: Oriental Prisons, by Arthur Griffiths)(not good) it occurred to me that there might have been some beneficial effect of the large amounts of tobacco smoke inside the prison. Sure, in the long run, tobacco is highly likely to give you cancer, but in the short run, is it noxious to fleas and other disease-bearing pests?

Meanwhile in Melanesia, (Pygmies and Papuans,) a group of ornithologists struggled up a river to reach an almost completely isolated tribe of Melanesians that barely practiced horticulture; even further up the mountain they met a band of pygmies (negritoes) whose existence had only been rumored of; the pygmies cultivated tobacco, which they traded with their otherwise not terribly interested in trading for worldy goods neighbors.

The homeless smoke at rates 3x higher than the rest of the population, though this might have something to do with the high correlation between schizophrenia and smoking–80% of schizophrenics smoke, compared to 20% of the general population. Obviously this correlation is best explained by tobacco’s well-noted psychological effects (including addiction,) but why is tobacco so ubiquitous in prisons that cigarettes are used as currency? Could they have, in unsanitary conditions, some healthful purpose?

From NPR: Pot For Parasites? Pygmy Men Smoke out Worms:

On average, the more THC byproduct that Hagen’s team found in an Aka man’s urine, the fewer worm eggs were present in his gut.

“The heaviest smokers, with everything else being equal, had about half the number of parasitic eggs in their stool, compared to everyone else,” Hagen says. …

THC — and nicotine — are known to kill intestinal worms in a Petri dish. And many worms make their way to the gut via the lungs. “The worms’ larval stage is in the lung,” Hagan says. “When you smoke you just blast them with THC or nicotine directly.”

Smithsonian reports that Birds Harness the Deadly Power of Nicotine to Poison Parasites:

Smoking kills. But if you’re a bird and if you want to kill parasites, that can be a good thing. City birds have taken to stuffing their nests with cigarette butts to poison potential parasites. Nature reports:

“In a study published today in Biology Letters, the researchers examined the nests of two bird species common on the North American continent. They measured the amount of cellulose acetate (a component of cigarette butts) in the nests, and found that the more there was, the fewer parasitic mites the nest contained.”

Out in the State of Nature, parasites are extremely common and difficult to get rid of (eg, hookworm elimination campaigns in the early 1900s found that 40% of school-aged children were infected); farmers can apparently use tobacco as a natural de-wormer (but be careful, as tobacco can be poisonous.)

In the pre-modern environment, when many people had neither shoes, toilets, nor purified water, parasites were very hard to avoid.
Befoundalive recommends eating the tobacco from a cigarette if you have intestinal parasites and no access to modern medicine.

Here’s a study comparing parasite rates in tobacco workers vs. prisoners in Ethiopia:

Overall, 8 intestinal parasite species have been recovered singly or in combinations from 146 (61.8 %) samples. The prevalence in prison population (88/121 = 72.7%) was significantly higher than that in tobacco farm (58/115 = 50.4%).

In vitro anthelmintic effect of Tobacco (Nicotiana tabacum) extract on parasitic nematode, Marshallagia marshalli reports:

Because of developing resistance to the existing anthelmintic drugs, there is a need for new anthelmintic agents. Tobacco plant has alkaloid materials that have antiparasitic effect. We investigated the in vitro anthelminthic effect of aqueous and alcoholic extract of Tobacco (Nicotiana tabacum) against M. marshalli. … Overall, extracts of Tobacco possess considerable anthelminthic activity and more potent effects were observed with the highest concentrations. Therefore, the in vivo study on Tobocco in animal models is recommended.

(Helminths are parasites; anthelmintic=anti-parasites.)

So it looks like, at least in the pre-sewers and toilets and clean water environment when people struggled to stay parasite free, tobacco (and certain other drugs) may have offered people an edge over the pests. (I’ve noticed many bitter or noxious plants seem to have been useful for occasionally flushing out parasites, but you certainly don’t want to be in a state of “flush” all the time.)

It looks like it was only when regular sanitation got good enough that we didn’t have to worry about parasites anymore that people started getting really concerned with tobacco’s long-term negative effects on humans.

The Big 6 Civilizations (Pt. 3: Indus Valley)

3. Indus Valley

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Map of the Indus Valley Civilization
Map of the Indus Valley Civilization

The Indus Valley civilization (IVC) has got to be the most obscure of the big six. If you challenged the average person to list the world’s first six relatively independent civilizations, they’d probably guess “Egypt, Mesopotamia, Greece, Rome, China, and, um, Africa? Israel?” Eventually they might hit on “Incas and Aztecs/Mayans,” which are geographically about right. But few would guess that the Indus Valley, located in modern-day Pakistan and India, was one of the world’s first three big civilizations, predating the Chinese by almost a millennium and a half.

This is partially explained by random luck: Egypt and Mesopotamia both feature in the Bible and are relatively easy to get to from Europe, (Egypt moreso than Mesopotamia,) and early archaeology appears to have been driven largely by a desire to uncover the truth behind the Homeric epics and the Bible. (And I have a much easier time accessing archaeological materials written in English.)

China is an enormous, famous country that has the resources to promote its own heritage, and the cultures of the Americas are famous because they’re nearby and because they’re included in the history of the conquering of the Americas, which we learned in school.

Pakistan, by contrast, is hard to get to, not part of the American colonial narrative, doesn’t feature in the Bible, and doesn’t have China’s fame and resources. On top of that, if the Wikipedia talk page on the Indus Valley Culture is correct, Pakistan may not be all that interested in the IVC due to it not being Muslim.

India, by contrast, proudly claims the IVC as part of its history–the IVC page is “part of a series on the history of India,” but not “part of a series on the history of Pakistan.”

Additionally, the IVC, while it left behind plenty of cities, buildings, etc., did not build the kind of monumental structures that draw tourists, like the Great Pyramids of Egypt or Chichen Itza, Mexico. More than a thousand IVC cities or settlements have been discovered, many with granaries, public baths, hydraulic systems, and obvious urban planning (their cities are laid out in grids with excellent-for-the-time sewer systems,) but almost no enormous temples, castles, pyramids, or other obviously ceremonial sites.

Indus Valley seals
Indus Valley seals

Also, we have no knowledge of their language and have yet to decipher any of their written language–if they had a written language at all. (Everything you want to know about the IVC script and why we haven’t deciphered it yet.)

The Egyptians helpfully covered their temples in hieroglyphics and left behind so many written records that we have things like Egyptian math textbooks containing fictional, satirical stories about how to not be a scribe. From Mesopotamia we have the Epic of Gilgamesh.

But from the IVC we have only short inscriptions–if they are inscriptions at all–most on small seals. Most of these inscriptions are only a few characters long, greatly hindering our ability to decipher them. We don’t know what they mean, or even if they are a written language at all.

What we do know:

IVC_MapThe IVC (aka the Harappan, after one of their chief cities,) emerged around 3,300 BC in what is now  Pakistan and India. It lasted for about 2,000 years; then essentially disappeared, its people either merging into other populations or migrating away. Over a thousand Harappan cities or settlements have been identified, most of them in Pakistan but a few in Afghanistan and a contested number in India. (Since India is eager to claim the IVC as its own, there are allegations that Indian archaeologists are inflating the number of significant sites on their side of the border.)

(Afghanistan, of course, does not have the resources for archaeology, but it is also really dry, so there probably weren’t that many sites there to start with.)

The IVC likely descended from the Mehrgarh culture (see map). Mehrgarh was a small farming settlement founded around 6,500 BC:

The earliest farming in the area was developed by semi-nomadic people using plants such as wheat and barley and animals such as sheep, goats and cattle. The settlement was established with simple mud buildings and most of them had four internal subdivisions. Numerous burials have been found, many with elaborate goods such as baskets, stone and bone tools, beads, bangles, pendants and occasionally animal sacrifices, with more goods left with burials of males. Ornaments of sea shell, limestone, turquoise, lapis lazuli and sandstone have been found, along with simple figurines of women and animals. Sea shells from far sea shore and lapis lazuli found as far away as present-day Badakshan, Afghanistan shows good contact with those areas. …

In April 2006, it was announced in the scientific journal Nature that the oldest (and first early Neolithic) evidence for the drilling of human teeth in vivo (i.e. in a living person) was found in Mehrgarh. According to the authors, their discoveries point to a tradition of proto-dentistry in the early farming cultures of that region. “Here we describe eleven drilled molar crowns from nine adults discovered in a Neolithic graveyard in Pakistan that dates from 7,500 to 9,000 years ago.”

Ouch.

Harappan toys?
Harappan toys?

Major IVC cities include Harappa, Mohenjo-daro, Dholavira, Ganeriwala, and Rakhigarhi.

[Harappa] is believed to have had as many as 23,500 residents and occupied about 150 hectares (370 acres) with clay sculptured houses

… Harappan society was not entirely peaceful, with the human skeletal remains demonstrating some of the highest rates of injury (15.5%) found in South Asian prehistory.[11] Paleopathological analysis demonstrated that leprosy and tuberculosis were present at Harappa, with the highest prevalence of both disease and trauma present in the skeletons from Area G (an ossuary located south-east of the city walls).[12] Furthermore, rates of cranio-facial trauma and infection increased through time, demonstrating that the civilization collapsed amid illness and injury.

Distribution of haplogroup L of Y-cromosome
Modern distribution of haplogroup L-M20

Genetically, Harappan skeletons belong to haplogroup L-M20, which today is found primarily in Pakistan and the west coast of India:

In Pakistan, it has highest frequency in Baluchistan.[2] In India, it has higher frequency among Dravidian castes, but is somewhat rarer in Indo-Aryan castes.[3] They make a case for an indigenous origin of L-M76 in India, by arguing that the spatial distributions of both L-M76 HG frequency and associated microsatellite variance show a pattern of spread emanating from southern India. By linking haplogroup L-M76 to the Dravidian speakers, they simultaneously argue for an Indian origin of Dravidian languages (Sengupta 2006).

There is apparently some controversy over whether the invading Indo-Europeans (who brought the Sanskrit language to India) drove the Harappans out of Pakistan and into India. India’s a big place that can absorb a lot of people, but it looks to me like many of the Harappans stayed put.

Mohenjo-Daro
Mohenjo-Daro, Pakistan

Meanwhile, in Mohenjo-Daro:

The Citadel – a mud-brick mound around 12 metres (39 ft) high – is known to have supported public baths, a large residential structure designed to house about 5,000 citizens, and two large assembly halls. The city had a central marketplace, with a large central well. Individual households or groups of households obtained their water from smaller wells. … Some houses … include rooms that appear to have been set aside for bathing, and one building had an underground furnace (known as a hypocaust), possibly for heated bathing. Most houses had inner courtyards, with doors that opened onto side-lanes. Some buildings had two stories.[citation needed]

The Great Bath of Mohenjo-daro
The Great Bath of Mohenjo-Daro

In 1950, Sir Mortimer Wheeler identified one large building in Mohenjo-daro as a “Great Granary”. Certain wall-divisions in its massive wooden superstructure appeared to be grain storage-bays, complete with air-ducts to dry the grain. … However, Jonathan Mark Kenoyer noted the complete lack of evidence for grain at the “granary”, which, he argued, might therefore be better termed a “Great Hall” of uncertain function.[13] Close to the “Great Granary” is a large and elaborate public bath, sometimes called the Great Bath. From a colonnaded courtyard, steps lead down to the brick-built pool, which was waterproofed by a lining of bitumen. The pool measures 12 metres (39 ft) long, 7 metres (23 ft) wide and 2.4 metres (7.9 ft) deep. … Other large buildings include a “Pillared Hall”, thought to be an assembly hall of some kind, and the so-called “College Hall”, a complex of buildings comprising 78 rooms, thought to have been a priestly residence.[citation needed]

Mohenjo-daro had no series of city walls, but was fortified with guard towers to the west of the main settlement, and defensive fortifications to the south. … Mohenjo-daro was successively destroyed and rebuilt at least seven times. Each time, the new cities were built directly on top of the old ones. Flooding by the Indus is thought to have been the cause of destruction.[citation needed]

Why is it all “citation needed”?

Dancing Girl of Mohenjo Daro
Dancing Girl of Mohenjo Daro

A bronze statuette dubbed the “Dancing Girl”, 10.5 centimetres (4.1 in) high[20] and about 4,500 years old, was found in ‘HR area’ of Mohenjo-daro in 1926.[20] … The archaeologist Gregory Possehl said of the statuette, “We may not be certain that she was a dancer, but she was good at what she did and she knew it”. The statue led to two important discoveries about the civilization: first, that they knew metal blending, casting and other sophisticated methods of working with ore, and secondly that entertainment, especially dance, was part of the culture.[20]

I think “dancer” is an overly-poetic interpretation of the statue, but it is a striking work.

"priest-king" statue, IVC
“Priest-King” statue, Mohenjo-daro

In 1927, this soapstone figurine, dubbed “The Priest-King,” (though we don’t know if the Mohenjo-daroians had priests or kings,) was found in a wall-niche in a “building with unusually ornamental brickwork.”

The sculpture is 17.5 centimetres (6.9 in) tall and depicts a bearded man with a fillet around his head, an armband, and a cloak decorated with trefoil patterns that were originally filled with red pigment. … Two holes beneath the highly stylized ears suggest that a necklace or other head ornament was attached to the sculpture. … Drill holes in the center of each circle indicate they were made with a specialized drill and then touched up with a chisel. The eyes are deeply incised and may have held inlay. …[22]

Dholavira, located in India:

Dholavira_LayoutOne of the unique features[14] of Dholavira is the sophisticated water conservation system[15] of channels and reservoirs, the earliest found anywhere in the world,[16] built completely of stone. The city had massive reservoirs, three of which are exposed.[17] They were used for storing fresh water brought by rains[15] or to store water diverted from two nearby rivulets.[18] This clearly came in response to the desert climate and conditions of Kutch, where several years may pass without rainfall. A seasonal stream which runs in a north-south direction near the site was dammed at several points to collect water. …

A huge circular structure on the site is believed to be a grave or memorial,[15] although it contained no skeletons or other human remains. The structure consists of ten radial mud-brick walls built in the shape of a spoked wheel.[15] … 

These hemispherical structures bear similarity to early Buddhist stupas.[5] The Archaeological Survey of India, which conducted the excavation, opines that “the kind of design that is of spoked wheel and unspoked wheel also remind one of the Sararata-chakra-citi and sapradhi-rata-chakra-citi mentioned in the Satapatha Brahmana and Sulba-sutras“.[5] …

Glyphs from the Dholavira sign board,
Glyphs from the Dholavira sign board

One of the most significant discoveries at Dholavira was made in one of the side rooms of the northern gateway of the city, and is generally known as the Dholavira Signboard. The Harappans had arranged and set pieces of the mineral gypsum to form ten large symbols or letters on a big wooden board[27] … Each sign is about 37 cm (15 in) high and the board on which letters were inscribed was about 3 m (9.8 ft) long.[28] The inscription is one of the longest in the Indus script, with one symbol appearing four times, and this and its large size and public nature make it a key piece of evidence cited by scholars arguing that the Indus script represents full literacy. A four sign inscription with big size letters on a sand stone is also found at this site, considered first of such inscription on sand stone at any of Harappan sites.[1]

More generally:

Indus Valley civilization was mainly an urban culture sustained by surplus agricultural production and commerce, the latter including trade with Sumer in southern Mesopotamia. Both Mohenjo-Daro and Harappa are generally characterized as having “differentiated living quarters, flat-roofed brick houses, and fortified administrative or religious centers.”[8] …
Distinctive seals were used, among other applications, perhaps for identification of property and shipment of goods. Although copper and bronze were in use, iron was not yet employed. “Cotton was woven and dyed for clothing; wheat, rice, and a variety of vegetables and fruits were cultivated; and a number of animals, including the humped bull, were domesticated,”[8] as well as “fowl for fighting“.[9] Wheel-made pottery—some of it adorned with animal and geometric motifs—has been found in profusion at all the major Indus sites. A centralized administration for each city, though not the whole civilization, has been inferred from the revealed cultural uniformity; however, it remains uncertain whether authority lay with a commercial oligarchy. Harappans had many trade routes along the Indus River that went as far as the Persian Gulf, Mesopotamia, and Egypt. Some of the most valuable things traded were carnelian and lapis lazuli.[10]

Obviously we don’t know much at all about IVC mathematics, but:

Excavations … have uncovered evidence of the use of “practical mathematics”. The people of the IVC manufactured bricks whose dimensions were in the proportion 4:2:1, considered favourable for the stability of a brick structure. They used a standardised system of weights based on the ratios: 1/20, 1/10, 1/5, 1/2, 1, 2, 5, 10, 20, 50, 100, 200, and 500, with the unit weight equaling approximately 28 grams … They mass-produced weights in regular geometrical shapes, which included hexahedra, barrels, cones, and cylinders, thereby demonstrating knowledge of basic geometry.[18]

The inhabitants of Indus civilisation also tried to standardise measurement of length to a high degree of accuracy. They designed a ruler—the Mohenjo-daro ruler—whose unit of length (approximately 1.32 inches or 3.4 centimetres) was divided into ten equal parts. Bricks manufactured in ancient Mohenjo-daro often had dimensions that were integral multiples of this unit of length.[19][20]

And the rather incomplete Wikipedia page on IVC hydraulics states:

Among other things, they contain the world’s earliest known system of flush toilets. These existed in many homes, and were connected to a common sewerage pipe. Most houses also had private wells. City walls functioned as a barrier against floods.

The urban areas of the Indus Valley civilization provided public and private baths, sewage was disposed through underground drains built with precisely laid bricks, and a sophisticated water management system with numerous reservoirs was established. In the drainage systems, drains from houses were connected to wider public drains.[1]

Lothal, a port city located in India, contains the world’s earliest known docks, and may have been a Harappan colony, far from the heartland of the IVC:

Before the arrival of Harappan people (c. 3000 BCE), Lothal was a small village next to the river providing access to the mainland from the Gulf of Khambhat. The indigenous people maintained a prosperous economy, attested by the discovery of copper objects, beads and semi-precious stones. … Harappans were attracted to Lothal for its sheltered harbour, rich cotton and rice-growing environment and bead-making industry. The beads and gems of Lothal were in great demand in the west. The settlers lived peacefully with the Red Ware people, who adopted their lifestyle, evidenced from the flourishing trade and changing working techniques. Harappans began producing the indigenous ceramic goods, adopting the manner from the natives.[8]

And, typical of the IVC:

The uniform organisation of the town and its institutions give evidence that the Harappans were a very disciplined people.[12] … Municipal administration was strict – the width of most streets remained the same over a long time, and no encroached structures were built. Householders possessed a sump, or collection chamber to deposit solid waste in order to prevent the clogging of city drains. Drains, manholes and cesspools kept the city clean and deposited the waste in the river, which was washed out during high tide. A new provincial style of Harappan art and painting was pioneered. The new approaches included realistic portrayals of animals in their natural surroundings. Metalware, gold and jewellery and tastefully decorated ornaments attest to the culture and prosperity of the people of Lothal.

Most of their equipment: metal tools, weights, measures, seals, earthenware and ornaments were of the uniform standard and quality found across the Indus civilization. Lothal was a major trade centre, importing en masse raw materials like copper, chert and semi-precious stones from Mohenjo-daro and Harappa, and mass distributing to inner villages and towns. It also produced large quantities of bronze celts, fish-hooks, chisels, spears and ornaments. Lothal exported its beads, gemstones, ivory and shells. The stone blade industry catered to domestic needs—fine chert was imported from the Larkana valley or from Bijapur in modern Karnataka. Bhagatrav supplied semi-precious stones while chank shell came from Dholavira and Bet Dwarka. An intensive trade network gave the inhabitants great prosperity. The network stretched across the frontiers to Egypt, Bahrain and Sumer.[11] One of the evidence of trade in Lothal is the discovery of typical Persian gulf seals, a circular button seal[13]

I love these descriptions, but given the politics involved, I remain wary that the case may be overstated.

So what happened to the IVC? There are many theories, ranging from the far-fetched (“aliens nuked it”) to the perfectly reasonable (“shifting weather patterns made the area too dry.”) Invasion by the Indo-Aryan people could also have destroyed many cities. A massive flood hit Lothal in 1900 BC, which destroyed much of the city. Wikipedia’s description of the aftermath reminds me of the post-apocalyptic nature of the collapse of Rome:

Archaeological evidence shows that the site continued to be inhabited, albeit by a much smaller population devoid of urban influences. The few people who returned to Lothal could not reconstruct and repair their city, but surprisingly continued to stay and preserved religious traditions, living in poorly built houses and reed huts. That they were the Harappan peoples is evidenced by the analyses of their remains in the cemetery. While the trade and resources of the city were almost entirely gone, the people retained several Harappan ways in writing, pottery and utensils. About this time ASI archaeologists record a mass movement of refugees from Punjab and Sindh into Saurashtra and to the valley of Sarasvati (1900–1700 BCE).[17] Hundreds of ill-equipped settlements have been attributed to this people as Late Harappans a completely de-urbanised culture characterised by rising illiteracy, less complex economy, unsophisticated administration and poverty.